ملخص البحث
Co-administration of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and antimicrobials may occur frequently because of worldwide in medical as well as veterinary practices. Often it is either diminished therapeutic efficacy or increased toxicity of one or more of the administered drugs. In this study the effect of pefloxacin/ diclofenac interaction was investigated on twenty clinically healthy goats of balady breed with an average body
weight (21-27 kg). Goats were injected i.m. with pefloxacin at dose rate of 5 mg/kg b.wt daily for 4 days consequently. Diclofenac sodium was injected i.m. at dose rate of 1 mg/kg b.wt daily for 4 days consequently to
different groups of goats . Two blood samples were collected from each animal of all groups at 3rd day, then at 1st , 2nd , 3rd week post injection. The obtained results revealed that co-administration of diclofenac sodium and
pefloxacin showed significant changes (p < 0.05) in total erythrothytic count (RBCs), haemoglobin (Hb) % and packed cell volume (PCV). no significant change in total leucocytic count . Drugs caused slight impairment of
hepatic and renal functions of goats. The effect of both drugs was short-lived and most of the parameters went back to normal after 2 weeks post drug(s) administration. [El-Ghoneimy A. A. and Shaheen H. M. Evaluation of hematological and biochemical effects of pefloxacin/ diclofenac interaction in goat. Life Sci J 2012;9(4):4847-4854] (ISSN:1097-8135). http://www.lifesciencesite.com. 729