عنوان البحث
Synthesis, computational, spectroscopic, thermal and antimicrobial activity studies on some metal–urate complexes
ملخص البحث
New sixteen uric acid metal complexes of different stoichiometry, stereo-chemistries and modes of interactions were synthesized using different metals Cr, Mn, Fe, Co, Ni, Cu, Cd, UO2, Na and K. The synthesized
complexes were characterized by elemental analysis, spectral (IR, UV–Vis and ESR) methods, thermal analysis (TG, DTA and DSC) and magnetic susceptibility studies. Molecular modeling calculations were
used to characterize the ligation sites of the free ligand. Furthermore, quantum chemical parameters of uric acid such as the energies of highest occupied molecular orbital (EHOMO), energies of lowest unoccupied
molecular orbital (ELUMO), the separation energy (E = ELUMO − EHOMO), the absolute electronegativity, , the chemical potential, Pi, the absolute hardness, and the softness () were obtained for uric acid. Eight
different microbial categories were used to study the antimicrobial activity of the free ligand and ten of its complexes. The results indicate that the ligand and its metal complexes possess antimicrobial properties.
The stoichiometry of iron–uric acid complex was studied by using different spectrophotometric methods.